BBBomics-Human Blood Brain Barrier Transcriptomics Hub

BBBomics-Human Blood Brain Barrier Transcriptomics Hub

Blood Brain Barrier Permeation

The large surface area and the short diffusion distance from capillaries of the blood brain barrier (BBB) to the neurons facilitate the drugs and nutrients access to the brain. Penetration of chemicals to the BBB occurs using a combination of intra and intercellular passages. Tight junctions regulate the intracellular passage of molecules according to their physicochemical properties (e.g. lipo...

The blood-brain barrier.

In autoimmune neurologic disorders, the blood-brain barrier (BBB) plays a central role in immunopathogenesis, since this vascular interface is an entry path for cells and effector molecules of the peripheral immune system to reach the target organ, the central nervous system (CNS). The BBB's unique anatomic structure and the tightly regulated interplay of its cellular and acellular components a...

Blood-brain Barrier Experiment

The graphical tools (see Section 4) showed that the logarithmic transformation applied to both the response (concentration ratio) and the explanatory variable sacrifice time makes the relationship between the two variables approximately linear. In this section we will examine the relationship between the logarithm of concentration ratio (LNRATIO) and the eight explanatory variables with the fol...

Blood-brain barrier genomics.

The blood-brain barrier (BBB) is formed by the brain microvascular endothelium, and the unique transport properties of the BBB are derived from tissue-specific gene expression within this cell. The current studies developed a gene microarray approach specific for the BBB by purifying the initial mRNA from isolated rat brain capillaries to generate tester cDNA. A polymerase chain reaction-based ...